Inhibitors of influenza virus polymerase acidic (PA) endonuclease: contemporary developments and perspectives

H Ju, J Zhang, B Huang, D Kang, B Huang… - Journal of Medicinal …, 2017 - ACS Publications
Influenza virus (IFV) causes periodic global influenza pandemics, resulting in substantial
socioeconomic loss and burden on medical facilities. Yearly variation in the effectiveness of …

Molecular features of influenza A (H1N1) pdm09 prevalent in Mexico during winter seasons 2012-2014

R Arellano-Llamas, L Alfaro-Ruiz, C Arriaga Canon… - PloS One, 2017 - journals.plos.org
Since the emergence of the pandemic H1N1pdm09 virus in Mexico and California, biannual
increases in the number of cases have been detected in Mexico. As observed in previous …

PA N substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities

M Hu, S Yuan, ZW Ye, K Singh, C Li… - Journal of General …, 2017 - microbiologyresearch.org
Substitutions in the PA N-terminus (PAN) of influenza A viruses are associated with viral
pathogenicity. During our previous study, which identified PAN-V63I and-A37S/I61T/V63I …

Metal-chelating properties and antiviral activity of some 2-hydroxyphenyl amides

M Carcelli, E Fisicaro, C Compari, L Contardi… - Polyhedron, 2017 - Elsevier
Influenza virus is an hot topic in medicinal chemistry and great efforts are ongoing for the
discover of new antivirals able to overcome problems related to resistant strains and …

Design and synthesis of novel pan-targeting anti-influenza agents

HY Sagong - 2017 - rucore.libraries.rutgers.edu
Influenza viruses are lipid-enveloped, negative-sense, single-strand RNA viruses, which
belong to the family of Orthomyxoviridae. 1 There are three types of viruses: A, B and C …

Influenza A 2009 pandemic H1N1 polypeptide fragments comprising endonuclease activity and their use

S Cusack, E Kowalinski, C Zubieta - US Patent 9,783,794, 2017 - Google Patents
2016-06-13 Assigned to EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)
reassignment EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) ASSIGNMENT …