Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …

Cellular signal transmission requires the dynamic formation of spatiotemporally controlled
molecular interactions. At the cell surface information is received by receptor complexes and …

Immune responses involve coordination across cell types and tissues. However, studies in
cancer immunotherapy have focused heavily on local immune responses in the tumor …

Cells operate through protein interaction networks organized in space and time. Here, we
describe an approach to resolve both dimensions simultaneously by using proximity …

Macromolecular protein complexes carry out many of the essential functions of cells, and
many genetic diseases arise from disrupting the functions of such complexes. Currently …

The aging process is driven at the cellular level by random molecular damage that slowly
accumulates with age. Although cells possess mechanisms to repair or remove damage …

Recent advances in high-throughput technologies have created exciting opportunities for
systematically investigating the molecular basis of human disease. In addition to a growing …

With combined technological advancements in high-throughput next-generation sequencing
and deep mass spectrometry-based proteomics, proteogenomics, ie the integrative analysis …

Ovarian cancer is one of the most significant disease among gynecological disorders that
women suffered from over the centuries. However, disease-specific and effective biomarkers …

Differential network analysis (DiNA) denotes a recent class of network-based Bioinformatics
algorithms which focus on the differences in network topologies between two states of a cell …