Naïve pluripotent mouse embryonic stem cells (ESCs) resemble the preimplantation epiblast
and efficiently contribute to chimaeras. Primate ESCs correspond to the postimplantation …

Stem cells (SCs) have been extensively studied in the context of regenerative medicine.
Human hematopoietic stem cell (HSC)-based therapies have been applied to treat leukemic …

Human pluripotent stem cells (hPSCs) have been reported in naive and primed states.
However, the ability to generate mature cell types remains the imperative property for utility …

Naked mole rats (NMRs) are exceptionally long-lived, cancer-resistant rodents. Identifying
the defining characteristics of these traits may shed light on aging and cancer mechanisms …

Interspecies chimeric assays are a valuable tool for investigating the potential of human
stem and progenitor cells, as well as their differentiated progeny. This Spotlight article …

The essential idea of regenerative medicine is to fix or replace tissues or organs with alive
and patient-specific implants. Pluripotent stem cells are able to indefinitely self-renew and …

The male germinal lineage, which is defined as unipotent, produces sperm through
spermatogenesis. However, embryonic primordial germ cells and postnatal spermatogonial …

Recent advances have demonstrated the power of small molecules in promoting cellular
reprogramming. Yet, the full potential of such chemicals in cell fate manipulation and the …

Molecular Approach to Cancer Management discusses molecular mechanisms of cancer
initiation, growth and secondary spread, emphasizing how this information can be used to …

Although a variety of reprogramming strategies have been reported to create transgene-free
induced pluripotent stem (iPS) cells from differentiated cell sources, a fundamental question …