Glu-ureido–based inhibitors of prostate-specific membrane antigen: lessons learned during the development of a novel class of low-molecular-weight theranostic …

K Kopka, M Benešová, C Bařinka… - Journal of Nuclear …, 2017 - Soc Nuclear Med
In recent years, several radioligands targeting prostate-specific membrane antigen (PSMA)
have been clinically introduced as a new class of theranostic radiopharmaceuticals for the …

[HTML][HTML] Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer

LH Schmidt, B Heitkötter, AB Schulze, C Schliemann… - PloS one, 2017 - journals.plos.org
Objectives PSMA (prostate-specific membrane antigen) is overexpressed in prostate cancer
cells and is reported to be a promising target for antibody-based radioligand therapy in …

PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer

LA Caromile, K Dortche, MM Rahman, CL Grant… - Science …, 2017 - science.org
Increased abundance of the prostate-specific membrane antigen (PSMA) on prostate
epithelium is a hallmark of advanced metastatic prostate cancer (PCa) and correlates …

18F-DCFPyL PET/CT in the detection of prostate cancer at 60 and 120 minutes: detection rate, image quality, activity kinetics, and biodistribution

M Wondergem, FM van der Zant, RJJ Knol… - Journal of Nuclear …, 2017 - Soc Nuclear Med
There is increasing interest in PET/CT with prostate-specific membrane antigen (PSMA)
tracers for imaging of prostate cancer because of the higher detection rates of prostate …

[HTML][HTML] Expression of PSMA in tumor neovasculature of high grade sarcomas including synovial sarcoma, rhabdomyosarcoma, undifferentiated sarcoma and MPNST

B Heitkötter, M Trautmann, I Grünewald, M Bögemann… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Aims PSMA (prostate specific membrane antigen) is physiologically expressed in normal
prostate tissue. It is overexpressed in prostate cancer cells and has been suggested as a …

Folate-targeted amphiphilic cyclodextrin nanoparticles incorporating a fusogenic peptide deliver therapeutic siRNA and inhibit the invasive capacity of 3D prostate …

JC Evans, M Malhotra, K Sweeney, R Darcy… - International journal of …, 2017 - Elsevier
The main barrier to the development of an effective RNA interference (RNAi) therapy is the
lack of a suitable delivery vector. Modified cyclodextrins have emerged in recent years for …

[HTML][HTML] 64Cu-PSMA-617: A novel PSMA-targeted radio-tracer for PET imaging in gastric adenocarcinoma xenografted mice model

XD Han, C Liu, F Liu, QH Xie, TL Liu, XY Guo, XX Xu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Here, we report that it's feasible for imaging gastric adenocarcinoma mice model with
prostate-specific membrane antigen (PSMA) targeting imaging agents, which could …

Pulmonary opacities and bronchiectasis avid on 68Ga-PSMA PET

K Bouchelouche, MH Vendelbo - Clinical nuclear medicine, 2017 - journals.lww.com
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and the
expression increases with tumor aggressiveness, metastatic disease, and recurrence …

Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII

T Knedlík, B Vorlová, V Navrátil, J Tykvart… - FEBS Open …, 2017 - Wiley Online Library
Glutamate carboxypeptidase II (GCPII), also known as prostate‐specific membrane antigen
(PSMA) or folate hydrolase, is a metallopeptidase expressed predominantly in the human …

Neovascular Prostate‐Specific Membrane Antigen Expression Is Associated with Improved Overall Survival under Palliative Chemotherapy in Patients with Pancreatic …

K Stock, K Steinestel, R Wiesch… - BioMed Research …, 2017 - Wiley Online Library
Aims. Expression of PSMA (prostate‐specific membrane antigen) has been demonstrated in
various cancers, including pancreatic ductal adenocarcinoma (PDAC). However, PSMA …