Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …

African Americans have a heightened risk of developing chronic and end-stage kidney
disease, an association that is largely attributed to two common genetic variants, termed G1 …

Fibrosis, a characteristic of all chronic kidney diseases, is now recognized to be an
independent predictor of disease progression. Deposition of pathological matrix in the walls …

Biomarkers of diverse pathophysiologic mechanisms may improve risk stratification for
incident or progressive diabetic kidney disease (DKD) in persons with type 2 diabetes. To …

Background and Aims. The nucleotide‐binding domain and leucine‐rich repeat containing
PYD‐3 (NLRP3) inflammasome has been implicated in the pathogenesis of chronic kidney …

Chronic kidney disease (CKD) has diverse phenotypic manifestations including structural
(such as fibrosis) and functional (such as glomerular filtration rate and albuminuria) …

Familial aggregation of chronic kidney disease and its component phenotypes—reduced
glomerular filtration rate, proteinuria and renal histologic changes—has long been …

Chronic kidney disease has severe impacts on the patient and represents a major burden to
the health care systems worldwide. Despite an increased knowledge of pathophysiological …

Abstract Serine/threonine kinases (WNK1, WNK4, SPAK, OSR1) and cation co-transporters
(NKCC2, NCC) are members of a multi-kinase network that determines renal Na+ …

Metabolic diseases, including fatty liver disease, hyperglycemia, and obesity, result when
body systems responsible for managing allostasis (dynamic homeostasis across systems) …