The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights
The vitamin D receptor (VDR) is the single known regulatory mediator of hormonal 1, 25-
dihydroxyvitamin D3 [1, 25 (OH) 2D3] in higher vertebrates. It acts in the nucleus of vitamin D …
dihydroxyvitamin D3 [1, 25 (OH) 2D3] in higher vertebrates. It acts in the nucleus of vitamin D …
Association analysis identifies 65 new breast cancer risk loci
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
RL Milne, KB Kuchenbaecker, K Michailidou… - Nature …, 2017 - nature.com
Most common breast cancer susceptibility variants have been identified through genome-
wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease …
wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease …
A benchmark of gene expression tissue-specificity metrics
N Kryuchkova-Mostacci… - Briefings in …, 2017 - academic.oup.com
One of the major properties of genes is their expression pattern. Notably, genes are often
classified as tissue specific or housekeeping. This property is of interest to molecular …
classified as tissue specific or housekeeping. This property is of interest to molecular …
Coordinated splicing of regulatory detained introns within oncogenic transcripts creates an exploitable vulnerability in malignant glioma
Glioblastoma (GBM) is a devastating malignancy with few therapeutic options. We identify
PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or inhibition …
PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or inhibition …
[HTML][HTML] Targeting of polycomb repressive complex 2 to RNA by short repeats of consecutive guanines
X Wang, KJ Goodrich, AR Gooding, H Naeem, S Archer… - Molecular cell, 2017 - cell.com
Summary Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that
trimethylates H3K27, a mark of repressed chromatin. Mammalian PRC2 binds RNA …
trimethylates H3K27, a mark of repressed chromatin. Mammalian PRC2 binds RNA …
Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies
Recent large-scale genetic approaches such as genome-wide association studies have
allowed the identification of common genetic variations that contribute to risk architectures of …
allowed the identification of common genetic variations that contribute to risk architectures of …
Combinatorial bZIP dimers display complex DNA-binding specificity landscapes
How transcription factor dimerization impacts DNA-binding specificity is poorly understood.
Guided by protein dimerization properties, we examined DNA binding specificities of 270 …
Guided by protein dimerization properties, we examined DNA binding specificities of 270 …
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
PS Wild, JF Felix, A Schillert, A Teumer… - The Journal of …, 2017 - Am Soc Clin Investig
BACKGROUND. Understanding the genetic architecture of cardiac structure and function
may help to prevent and treat heart disease. This investigation sought to identify common …
may help to prevent and treat heart disease. This investigation sought to identify common …
[HTML][HTML] Nicotinamide metabolism regulates glioblastoma stem cell maintenance
Metabolic dysregulation promotes cancer growth through not only energy production, but
also epigenetic reprogramming. Here, we report that a critical node in methyl donor …
also epigenetic reprogramming. Here, we report that a critical node in methyl donor …