Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics
ML Pearn, IR Niesman, J Egawa, A Sawada… - Cellular and molecular …, 2017 - Springer
Traumatic brain injury (TBI) is one of the leading causes of death of young people in the
developed world. In the United States alone, 1.7 million traumatic events occur annually …
developed world. In the United States alone, 1.7 million traumatic events occur annually …
Protein palmitoylation in the development and plasticity of neuronal connections
AK Globa, SX Bamji - Current opinion in neurobiology, 2017 - Elsevier
Highlights•Protein palmitoylation can regulate neurite outgrowth and synapse
plasticity.•Actin binding proteins, CAMs and synaptic proteins are palmitoylation …
plasticity.•Actin binding proteins, CAMs and synaptic proteins are palmitoylation …
Posttranslational modifications regulate the postsynaptic localization of PSD-95
D Vallejo, JF Codocedo, NC Inestrosa - Molecular neurobiology, 2017 - Springer
The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that
organizes and stabilizes synaptic receptors, ion channels, structural proteins, and signaling …
organizes and stabilizes synaptic receptors, ion channels, structural proteins, and signaling …
Neuron-targeted caveolin-1 improves molecular signaling, plasticity, and behavior dependent on the hippocampus in adult and aged mice
Background Studies in vitro demonstrate that neuronal membrane/lipid rafts (MLRs)
establish cell polarity by clustering progrowth receptors and tethering cytoskeletal machinery …
establish cell polarity by clustering progrowth receptors and tethering cytoskeletal machinery …
Glycosylphosphatidylinositol-anchored immunoglobulin superfamily cell adhesion molecules and their role in neuronal development and synapse regulation
RPA Tan, I Leshchyns' ka, V Sytnyk - Frontiers in molecular …, 2017 - frontiersin.org
Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface
glycoproteins that not only mediate interactions between neurons but also between neurons …
glycoproteins that not only mediate interactions between neurons but also between neurons …
Nuclear fragments of the neural cell adhesion molecule NCAM with or without polysialic acid differentially regulate gene expression
N Westphal, T Theis, G Loers, M Schachner… - Scientific reports, 2017 - nature.com
The neural cell adhesion molecule (NCAM) is the major carrier of polysialic acid (PSA)
which modulates NCAM functions of neural cells at the cell surface. In previous studies, we …
which modulates NCAM functions of neural cells at the cell surface. In previous studies, we …
Generation and intracellular trafficking of a polysialic acid-carrying fragment of the neural cell adhesion molecule NCAM to the cell nucleus
Polysialic acid (PSA) and its major protein carrier, the neural cell adhesion molecule NCAM,
play important roles in many nervous system functions during development and in …
play important roles in many nervous system functions during development and in …
NCAM-140 translocation into lipid rafts mediates the neuroprotective effects of GDNF
L Li, H Chen, M Wang, F Chen, J Gao, S Sun, Y Li… - Molecular …, 2017 - Springer
Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for
substantia nigra dopaminergic (DA) neuronal cells. Recent studies have demonstrated that …
substantia nigra dopaminergic (DA) neuronal cells. Recent studies have demonstrated that …
Form and Function in the Scn1b-null Cerebellar Cortex: Implications for Epileptic Encephalopathy
J Winters - 2017 - deepblue.lib.umich.edu
Dravet syndrome is a catastrophic, pediatric epileptic encephalopathy which is caused by
genetic mutations is voltage-gated Na+ channel (VGSC) subunit genes. In addition to severe …
genetic mutations is voltage-gated Na+ channel (VGSC) subunit genes. In addition to severe …
Functional role of a polysialic acid-carrying proteolytic fragment of the neural cell adhesion molecule NCAM in the nervous system
N Westphal - 2017 - ediss.sub.uni-hamburg.de
The membrane-associated glycoprotein NCAM is the main carrier of the unusual glycan α2,
8-linked polysialic acid (PSA) in the mammalian nervous system. PSA-NCAM is involved in …
8-linked polysialic acid (PSA) in the mammalian nervous system. PSA-NCAM is involved in …