For decades, identifying the regions of a bacterial chromosome that are necessary for
viability has relied on mapping integration sites in libraries of random transposon mutants to …

The cell membrane or biofilm serve as permeable barrier for xenobiotics to maintain the
homeostasis of cells or bacterial community. Transport systems are essential for the uptake …

Transcriptional regulatory networks (TRNs) have been studied intensely for> 25 y. Yet, even
for the Escherichia coli TRN—probably the best characterized TRN—several questions …

Highlights•Genomic and transcriptional analyses have paved the way to study
Mycobacterium tuberculosis (Mtb) at a molecular level.•Shotgun-MS, S/MRM and …

ESX (ESAT-6 system) export systems play diverse roles across mycobacterial species.
Interestingly, genetic disruption of ESX systems in different species does not result in an …

Mycobacterium tuberculosis has succeeded as a human pathogen for tens of thousands of
years thanks to its ability to resist and adapt to the adverse conditions it encounters upon …

Abstract Background Enteric Escherichia coli survives the highly acidic environment of the
stomach through multiple acid resistance (AR) mechanisms. The most effective system, AR2 …

Background Multidrug-resistant tuberculosis poses a major threat to the success of
tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis …

The cell envelope of mycobacteria is a highly unique and complex structure that is
functionally equivalent to that of Gram-negative bacteria to protect the bacterial cell. Defects …

MarR family proteins are transcriptional regulators that control expression of bacterial
proteins involved in metabolism, virulence, stress responses and multi-drug resistance …