Background: The tumor suppressor PTEN serves as a negative regulator of PI3K/PTEN/Akt
signaling pathway that regulates cellular functions such as cell growth, differentiation …

Although platinum-based chemotherapy remains the standard treatment for advanced
NSCLC patients, clinical outcomes are poor and most patients develop high-grade toxicities …

Abstract Background MiR-101-3p is an important tumor suppressor miRNA in many human
cancers. This study was to investigate the role of miR-101-3p in the progression of non-small …

Background/Aims: Recently, long non-coding RNAs (lncRNAs) have been found to have
many biological effects in different cancer stages. Several studies have revealed that focally …

Hexokinases II (HK2) is a hub in the regulation of cancer cell glycolysis. Here we reported
deguelin, a natural compound which has been studied in various tumor types, has a …

Histone deacetylases (HDACs) are crucial for regulating chromatin activity, which plays a
critical role in cell proliferation, differentiation, and apoptosis of various cancers. Therefore …

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have obtained
excellent therapeutic effects against non-small cell lung cancer (NSCLC) harboring …

MicroRNAs are small, endogenous, and non-coding RNAs that play important regulatory
roles in multiple biological processes in cancers. Recent evidence has indicated that miR …

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a lipid and protein
phosphatase and possesses an antitumor effect in lung cancers. miRNAs are reportedly …

Hypoxia‐induced chemoresistance remains a major obstacle to treating osteosarcoma
effectively. Mxd1, a member of the Myc/Max/Mxd family, was shown to be involved in the …