Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …

Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol
consumption and/or other metabolic disorder causes, lead to serious medical concerns …

Animal lifespan is regulated by conserved metabolic signalling pathways and specific
transcription factors, but whether these pathways affect common downstream mechanisms …

Premature aging disorders provide an opportunity to study the mechanisms that drive aging.
In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold …

Aging of organisms begins from a single cell at the molecular level. It includes changes
related to telomere shortening, cell senescence and epigenetic modifications. These …

Silent information regulator factor 2-related enzyme 1 (sirtuin 1, Sirt1) is a nicotinamide
adenine dinucleotide-dependent deacetylase, which can deacetylate histone and non …

Mature differentiated macrophages can self‐maintain by local proliferation in tissues and
can be extensively expanded in culture under specific conditions, but the mechanisms of this …

Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its
potential therapeutic use in the treatment of many diseases, including cancer, diabetes …

Investigations aimed at defining the 3D configuration of eukaryotic chromosomes have
consistently encountered an endogenous population of chromosome-derived circular …

The nucleolus is the subnuclear membrane-less organelle where rRNA is transcribed and
processed and ribosomal assembly occurs. During the last 20 years, however, the nucleolus …