Vitamin D deficiency accelerates ageing and age‐related diseases: a novel hypothesis

MJ Berridge - The Journal of physiology, 2017 - Wiley Online Library
Ageing can occur at different rates, but what controls this variable rate is unknown. Here I
have developed a hypothesis that vitamin D may act to control the rate of ageing. The basis …

Alzheimer's disease pathology and the unfolded protein response: prospective pathways and therapeutic targets

DJ Koss, B Platt - Behavioural pharmacology, 2017 - journals.lww.com
Many vital interdependent cellular functions including proteostasis, lipogenesis and Ca 2+
homeostasis are executed by the endoplasmic reticulum (ER). Exogenous insults can impair …

[HTML][HTML] Expression profiles and function analysis of microRNAs in postovulatory aging mouse oocytes

TY Wang, J Zhang, J Zhu, HY Lian, HJ Yuan… - Aging (Albany …, 2017 - ncbi.nlm.nih.gov
In this study, microRNA (miRNA) profiles in postovulatory aging mouse oocytes were
analyzed by microarray screening and RT-qPCR. Hierarchical cluster analysis on the …

Inhibition and conformational change of SERCA3b induced by Bcl-2

A Hewarathna, E Dremina, C Schöneich - Biochimica et Biophysica Acta …, 2017 - Elsevier
An interaction of Bcl-2 with SERCA had been documented in vitro using the SERCA1a
isoform isolated from rat skeletal muscle [Dremina, ES, Sharov, VS, Kumar, K., Azidi, A …

Muscle energetics and ageing in the context of RYR1 variants.

KM Nicoll Baines - 2017 - etheses.whiterose.ac.uk
In aged muscle, from humans and mice, the ryanodine receptor (RyR1) is leaky, leading to
increased levels of resting Ca2+ in the myoplasm. This is also a feature of skeletal muscle …

[PDF][PDF] Virally Induced Salivary Gland Hypofunction and Inflammation

AMKA Shaalan - 2017 - kclpure.kcl.ac.uk
A long association has been established between infectious inflammation and diseases of
the salivary glands (SGs). However, the prompt responses of the exocrine tissues to these …