Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes tri-methylation
of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic …

Epigenetic modifications in cancer stem cells largely result in phenotypic and functional
heterogeneity in many solid tumors. Increasing evidence indicates that enhancer of zeste …

We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2)
is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the …

Purpose: Deregulation or mutation of the EZH2 gene causes various tumors, including clear
cell renal cell carcinoma (ccRCC). Although several splice variants of EZH2 have been …

Abstract Enhancer of zeste 2 (Ezh2) mainly methylates lysine 27 of histone‐H3 (H3K27me3)
as part of the polycomb repressive complex 2 (PRC 2) together with Suz12 and Eed …

Summary Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 at lysine 27
(H3K27) and is required to maintain gene repression during development. Misregulation of …

Wnt/β-catenin signaling is required for embryonic stem cell (ESC) pluripotency by inducing
mesodermal differentiation and inhibiting neuronal differentiation; however, how β-catenin …

Understanding the mechanisms that regulate cell type-specific transcriptional programs
requires developing a lexicon of their genomic regulatory elements. We developed a …

Background & Aims Patterning of the small intestinal epithelium along its cephalocaudal
axis establishes three functionally distinct regions: duodenum, jejunum, and ileum. Efficient …

In proliferating cells, where most Polycomb repressive complex 2 (PRC2) studies have been
performed, gene repression is associated with PRC2 trimethylation of H3K27 (H3K27me3) …