CRISPR–Cas9 has revolutionized the generation of transgenic animals. This system has
demonstrated an unprecedented efficiency, multiplexability, and ease of use, thereby …

The composition of the porcine virome includes viruses that infect pig cells, ancient virus-
derived elements including endogenous retroviruses inserted in the pig chromosomes, and …

Despite being time-consuming and costly, generating genome-edited pigs holds great
promise for agricultural, biomedical, and pharmaceutical applications. To further facilitate …

FIGURE 3 Internal data showing PERVs infection to human primary cells such as HUVEC| 3
of 4 COMMENTARY xenotransplantation. 2 We cannot agree more with this statement. If …

The pig heart is a candidate organ for xenotransplantation, but endogenous retroviruses
(ERVs) in the pig genome can infect human cells in vitro, raising the specter of zoonotic …

In a recent issue of Science, the group of George Church at Harvard Medical School and
Luhan Yang at the Boston-based company eGenesis, in collaboration with groups in China …

Chimeric animals are made up of cells from two separate zygotes. Human/non-human
animal chimeras have been used for a number of research purposes, including human …

Diabetes is a common and important complication of cystic fibrosis, an autosomal recessive
genetic disease due to mutations in the cystic fibrosis transmembrane conductance …

Xenotransplantation, where tissue from one species is transplanted into a different species,
is currently under development to help alleviate the increasing shortage of human tissues …

Overall, the science of heart transplantation, and transplantation writ large, has seen major
advances over the last 50 years. Some of these advances have already benefited patients …