Background Current influenza virus vaccines are effective when well matched to the
circulating strains. Unfortunately, antigenic drift and the high diversity of potential emerging …

Antibodies are an important component in host immune responses to viral pathogens.
Because of their unique maturation process, antibodies can evolve to be highly specific to …

Antibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in
individuals who develop high titers of anti-ZIKV antibodies, we screened cohorts in Brazil …

Influenza virus evolves rapidly to constantly escape from natural immunity. Most humoral
immune responses to influenza virus target the hemagglutinin (HA) glycoprotein, which is …

Influenza antiviral drugs are important for the control of influenza, most specifically for the
treatment of influenza patients with severe disease following infection with a seasonal …

Highlights•Broadly neutralizing antibodies against influenza A and B represents a safe and
affordable alternative to convalescent plasma.•The large majority of broadly neutralizing …

Antibodies (Abs) produced by immunoglobulin (IG) genes are the most diverse proteins
expressed in humans. While part of this diversity is generated by recombination during B …

Antibodies that target both group 1 and group 2 influenza A viruses are valuable for
therapeutic and vaccine development, but only a few have been reported to date. Here, we …

Antigenic drift and shift of influenza strains underscore the need for broadly protective
influenza vaccines. One strategy is to design immunogens that elicit B cell responses …

Antibodies are the principal immune effectors that mediate protection against reinfection
following viral infection or vaccination. Robust techniques for human mAb isolation have …