Neuroimmunology of traumatic brain injury: time for a paradigm shift

YN Jassam, S Izzy, M Whalen, DB McGavern… - Neuron, 2017 - cell.com
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches

AL Boxer, JT Yu, LI Golbe, I Litvan, AE Lang… - The Lancet …, 2017 - thelancet.com
Progressive supranuclear palsy (PSP), previously believed to be a common cause of
atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes …

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

SL DeVos, RL Miller, KM Schoch, BB Holmes… - Science translational …, 2017 - science.org
Accumulation of hyperphosphorylated tau directly correlates with cognitive decline in
Alzheimer's disease and other primary tauopathies. One therapeutic strategy may be to …

Tau-based therapies in neurodegeneration: opportunities and challenges

C Li, J Götz - Nature Reviews Drug Discovery, 2017 - nature.com
Aggregates of the microtubule-associated protein tau are a defining feature of several
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …

A brief overview of tauopathy: causes, consequences, and therapeutic strategies

ME Orr, AC Sullivan, B Frost - Trends in pharmacological sciences, 2017 - cell.com
There are currently no disease-modifying therapies for the treatment of tauopathies, a group
of progressive neurodegenerative disorders that are pathologically defined by the presence …

Repeated mild traumatic brain injury: potential mechanisms of damage

B Fehily, M Fitzgerald - Cell transplantation, 2017 - journals.sagepub.com
Mild traumatic brain injury (mTBI) represents a significant public healthcare concern,
accounting for the majority of all head injuries. While symptoms are generally transient …

Amyloidogenesis of Tau protein

B Nizynski, W Dzwolak, K Nieznanski - Protein Science, 2017 - Wiley Online Library
The role of microtubule‐associated protein Tau in neurodegeneration has been extensively
investigated since the discovery of Tau amyloid aggregates in the brains of patients with …

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation

WA McEwan, B Falcon, M Vaysburd… - Proceedings of the …, 2017 - National Acad Sciences
Alzheimer's disease (AD) and other neurodegenerative disorders are associated with the
cytoplasmic aggregation of microtubule-associated protein tau. Recent evidence supports …

Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae

O Albayram, A Kondo, R Mannix, C Smith… - Nature …, 2017 - nature.com
Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and
associated with the development of chronic traumatic encephalopathy (CTE) and …

Brain injury in women experiencing intimate partner-violence: neural mechanistic evidence of an “invisible” trauma

E Valera, A Kucyi - Brain imaging and behavior, 2017 - Springer
Traumatic brain injury (TBI) in women experiencing intimate-partner violence (IPV) is
common, and IPV afflicts 30% of women worldwide. However, the neurobiology and related …