Maintenance of skeletal muscle mass is regulated by the balance between anabolic and
catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved …

Loss of skeletal muscle mass is a characteristic feature of various pathologies including
cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the …

Aging is a complex process characterized by progressive multisystem derangement
predisposing individuals to increased risk of developing negative health outcomes …

The quality control of skeletal muscle is a continuous requirement throughout the lifetime,
although its functions and quality present as a declining trend during aging process …

Highlights•The function of the autophagy/lysosome system declines during skeletal muscle
aging.•Boosting basal autophagy protects from sarcopenia.•Autophagy inhibition impedes …

Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Muscle loss occurs as a consequence of several chronic diseases (cachexia) …

Key points Muscle atrophy is a debilitating condition that affects a high percentage of the
population with a negative impact on quality of life. Dissecting the molecular level of the …

Klinefelter syndrome (KS) is the most common sex chromosomal disorder in males. Key
findings in older adolescents and young men are small testes with variable hypo …

The aging process induces significant changes in skeletal muscle morphology and
functionality. If not counteracted, this process, termed sarcopenia, can lead to progressively …

Many factors contribute to the decline of skeletal muscle that occurs as we age. This is a
reality that we may combat, but not prevent because it is written into our genome. The series …