This article first reviews recent developments in process synthesis and discusses some of
the major challenges in the theory and practice in this area. Next, the article reviews key …

Feasibility analysis is used to determine the feasible region of a multivariate process. This
can be difficult when the process models include black‐box constraints or the simulation is …

A near-global optimization approach is proposed to design blending recipes for refinery
products under uncertainties. In the refining industry, the most valuable products, such as …

Process systems engineering faces increasing demands and opportunities for better
process modeling and optimization strategies, particularly in the area of dynamic operations …

A systematic framework for Design Operability and Retrofit Analysis (DORA) is presented.
DORA is a framework explicitly analyzing energy system design containing process units …

A systematic approach is presented to retrofit design of a hydrogen distribution network. A
methodology is based on the steady-state flexibility index (FI s) for optimizing network and …

In this article, we develop a new approximate method of solving optimization problems with
joint chance constraints for the case when the uncertain parameters are independent …

Traditionally, design and control decisions are made in sequential stages over the life cycle
of a chemical plant. In the design phase, the optimal operating conditions and the …

The concept of design space (DS) in pharmaceutical development has become a very
critical aspect of Quality by Design and assurance of quality in manufacturing of …

Uncertainty affects industrial systems in many ways. It may describe the amount of system
variability. It may influence the way we make decisions. This paper provides a novel …