Aging of organisms begins from a single cell at the molecular level. It includes changes
related to telomere shortening, cell senescence and epigenetic modifications. These …

Chromatin structure is a major barrier to gene transcription that must be disrupted and re-set
during each round of transcription. Central to this process is the Set2/SETD2 …

Background Age-associated epigenetic changes are implicated in aging. Notably, age-
associated DNA methylation changes comprise a so-called aging “clock”, a robust …

Isogenic cells in a common environment show substantial cell-to-cell variation in gene
expression, often referred to as" expression noise." Here, we use multiple single-cell RNA …

Set2-mediated histone methylation at H3K36 regulates diverse activities, including DNA
repair, mRNA splicing, and suppression of inappropriate (cryptic) transcription. Although …

Aging is accompanied by a decline in tissue function, regeneration, and repair. A large part
of this decline is caused by the deterioration of tissue stem cell function. Understanding the …

In yeast, heterochromatin silencing is reported to decline in aging mother cells, causing
sterility in old cells. This process is thought to reflect a decrease in the activity of the NAD+ …

An organism's well-being is facilitated by numerous molecular and biochemical pathways
that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the …

Histone N‐terminal tails of nucleosomes are the sites of complex regulation of gene
expression through post‐translational modifications. Among these modifications, histone …

Histone post-translational modifications (PTM) as one of the key epigenetic regulatory
mechanisms that plays critical role in various biological processes, including regulating …