There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …

Microglia are brain-resident myeloid cells that mediate key functions to support the CNS.
Microglia express a wide range of receptors that act as molecular sensors, which recognize …

The spreading of pathology within and between brain areas is a hallmark of
neurodegenerative disorders. In patients with Alzheimer's disease, deposition of amyloid-β …

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–
control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole …

INTRODUCTION Microglia play essential roles in central nervous system homeostasis and
influence diverse aspects of neuronal function, including refinement of synaptic networks …

Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of …

Alzheimer's disease (AD) is a highly heritable complex disease with no current effective
prevention or treatment. The majority of drugs developed for AD focus on the amyloid …

We report a multi-omic resource generated by applying quantitative trait locus (xQTL)
analyses to RNA sequence, DNA methylation and histone acetylation data from the …

Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …