A review on neuroimaging-based classification studies and associated feature extraction methods for Alzheimer's disease and its prodromal stages

S Rathore, M Habes, MA Iftikhar, A Shacklett… - NeuroImage, 2017 - Elsevier
Neuroimaging has made it possible to measure pathological brain changes associated with
Alzheimer's disease (AD) in vivo. Over the past decade, these measures have been …

[HTML][HTML] The blood-brain barrier in Alzheimer's disease

E Zenaro, G Piacentino, G Constantin - Neurobiology of disease, 2017 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …

[18F]FDG PET signal is driven by astroglial glutamate transport

ER Zimmer, MJ Parent, DG Souza, A Leuzy… - Nature …, 2017 - nature.com
Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here
we provide positron emission tomography evidence that activation of astrocytic glutamate …

Imaging biomarkers in Parkinson's disease and Parkinsonian syndromes: current and emerging concepts

U Saeed, J Compagnone, RI Aviv, AP Strafella… - Translational …, 2017 - Springer
Two centuries ago in 1817, James Parkinson provided the first medical description of
Parkinson's disease, later refined by Jean-Martin Charcot in the mid-to-late 19th century to …

Quantification of brain cholinergic denervation in Alzheimer's disease using PET imaging with [18F]-FEOBV

M Aghourian, C Legault-Denis, JP Soucy… - Molecular …, 2017 - nature.com
Abstract 18 F-fluoroethoxybenzovesamicol (FEOBV) is a new PET radiotracer that binds to
the vesicular acetylcholine transporter. In both animals and healthy humans, FEOBV was …

The diagnostic value of FDG and amyloid PET in Alzheimer's disease—A systematic review

L Rice, S Bisdas - European journal of radiology, 2017 - Elsevier
Purpose By 2050 it is projected that 115 million people worldwide will have Alzheimer's
Disease (AD)[1]. Recent attempts have been made to redefine the diagnostic criteria of AD …

Blood-brain glucose transfer in Alzheimer's disease: effect of GLP-1 analog treatment

M Gejl, B Brock, L Egefjord, K Vang, J Rungby… - Scientific reports, 2017 - nature.com
There are fewer than normal glucose transporters at the blood-brain barrier (BBB) in
Alzheimer's disease (AD). When reduced expression of transporters aggravates the …

Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery

L Mosconi, V Berti, C Guyara-Quinn, P McHugh… - PloS one, 2017 - journals.plos.org
After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The
biological mechanisms underlying the increased AD risk in women remain largely …

Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease

AE Leeuwis, MR Benedictus, JPA Kuijer… - Alzheimer's & …, 2017 - Elsevier
Introduction We examined the association between decreased cerebral blood flow (CBF)
and cognitive impairment in Alzheimer's disease (AD), mild cognitive impairment (MCI), and …

Independent component analysis-support vector machine-based computer-aided diagnosis system for Alzheimer's with visual support

L Khedher, IA Illán, JM Górriz, J Ramírez… - … journal of neural …, 2017 - World Scientific
Computer-aided diagnosis (CAD) systems constitute a powerful tool for early diagnosis of
Alzheimer's disease (AD), but limitations on interpretability and performance exist. In this …