A current view of perlecan in physiology and pathology: a mosaic of functions

MA Gubbiotti, T Neill, RV Iozzo - Matrix biology, 2017 - Elsevier
Perlecan, a large basement membrane heparan sulfate proteoglycan, is expressed in a
wide array of tissues where it regulates diverse cellular processes including bone formation …

Platelet factor 4 binds to vascular proteoglycans and controls both growth factor activities and platelet activation

MS Lord, B Cheng, BL Farrugia, S McCarthy… - Journal of Biological …, 2017 - ASBMB
Platelet factor 4 (PF4) is produced by platelets with roles in both inflammation and wound
healing. PF4 is stored in platelet α-granules bound to the glycosaminoglycan (GAG) chains …

Recombinant domain V of human perlecan is a bioactive vascular proteoglycan

J Rnjak‐Kovacina, F Tang, X Lin… - Biotechnology …, 2017 - Wiley Online Library
The C‐terminal domain V of the extracellular matrix proteoglycan perlecan plays unique and
often divergent roles in a number of biological processes, including angiogenesis, vascular …

Platelets as Regulators of Thrombosis and Inflammation

D Duerschmied, S Massberg - Platelets, Haemostasis and Inflammation, 2017 - Springer
This chapter describes features of blood platelets that serve in the regulation of thrombosis
and inflammation. Classically, platelets have been known for decades to promote …