Metformin is a widely-used drug that results in clear benefits in relation to glucose
metabolism and diabetes-related complications. The mechanisms underlying these benefits …

Cancer immunotherapy is an increasingly successful strategy for the treatment of patients
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …

Various mechanisms in the mammalian body provide resilience against food deprivation
and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from …

Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance
on fatty acid metabolism and production of ketone bodies. We investigated whether an …

Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …

Caenorhabditis elegans is a small nematode that can be maintained at low cost and
handled using standard in vitro techniques. Unlike toxicity testing using cell cultures, C …

This systematic review investigated whether the insulin sensitiser metformin has a
geroprotective effect in humans. Pubmed and Embase were searched along with databases …

Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. In recent years,
in addition to glucose lowering, several studies have presented evidence suggesting some …

Mitochondria are important signalling organelles, and they dictate immunological fate. From
T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that …

Mitochondrial network remodeling between fused and fragmented states facilitates
mitophagy, interaction with other organelles, and metabolic flexibility. Aging is associated …