Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high
incidence of distant metastasis and recurrence. Cancer stem cells (CSCs), which are …

Pediatric high-grade gliomas (pHGG), including diffuse intrinsic pontine gliomas (DIPG), are
the most lethal types of cancer in children. In recent years, it has become evident that these …

Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a
subpopulation of glioma stem‐like cells (GSCs) is likely responsible for the invariable …

The oxygen tensions and matrix stiffness play important roles in regulating cell response to
cytotoxic drugs. In recent years, single spatiotemporal oxygen or matrix stiffness gradient …

In vivo, mammalian cells reside in an environment of 0.5–10% O 2 (depending on the tissue
location within the body), whilst standard in vitro cell culture is carried out under room air …

Gaseous microenvironments play important roles in various biological activities in vivo.
However, it is challenging to precisely control gaseous microenvironments in vitro for cell …

Aim: To investigate the time profile of hypoxia and stem cell markers in glioblastoma
spheroids of known molecular subtype. Materials & methods: Patient-derived glioblastoma …

Cancer cells display a higher level of reactive oxygen species (ROS) mainly due to
increased metabolic activities resulting in altered redox balance. Imbalance in redox arises …

Malignant brain tumors are a heterogeneous group of diseases arising from different cell
types that affect both adults and children. The high recurrence rate of malignant brain tumors …

Methods: Glioma specimens were obtained from 35 patients after surgery comprised of 20
low-grade and 15 highgrade tumors. Expression of mRNA CD133, HIF-1α and Oct-4 were …