Facing up to the global challenges of ageing
L Partridge, J Deelen, PE Slagboom - Nature, 2018 - nature.com
Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …
people experience little ill health, a trait that should be extended to the general population …
The personal and clinical utility of polygenic risk scores
A Torkamani, NE Wineinger, EJ Topol - Nature Reviews Genetics, 2018 - nature.com
Initial expectations for genome-wide association studies were high, as such studies
promised to rapidly transform personalized medicine with individualized disease risk …
promised to rapidly transform personalized medicine with individualized disease risk …
Behavioral weight loss interventions to prevent obesity-related morbidity and mortality in adults: US Preventive Services Task Force recommendation statement
Importance More than 35% of men and 40% of women in the United States are obese.
Obesity is associated with health problems such as increased risk for coronary heart …
Obesity is associated with health problems such as increased risk for coronary heart …
Nontraditional risk factors in cardiovascular disease risk assessment: updated evidence report and systematic review for the US Preventive Services Task Force
JS Lin, CV Evans, E Johnson, N Redmond… - Jama, 2018 - jamanetwork.com
Importance Incorporating nontraditional risk factors may improve the performance of
traditional multivariable risk assessment for cardiovascular disease (CVD). Objective To …
traditional multivariable risk assessment for cardiovascular disease (CVD). Objective To …
Lipid management in patients with chronic kidney disease
An increased risk of cardiovascular disease, independent of conventional risk factors, is
present even at minor levels of renal impairment and is highest in patients with end-stage …
present even at minor levels of renal impairment and is highest in patients with end-stage …
Screening for atrial fibrillation with electrocardiography: US Preventive Services Task Force recommendation statement
Importance Atrial fibrillation is the most common type of cardiac arrhythmia (irregular
heartbeat), and its prevalence increases with age, affecting about 3% of men and 2% of …
heartbeat), and its prevalence increases with age, affecting about 3% of men and 2% of …
Risk assessment for cardiovascular disease with nontraditional risk factors: US preventive services task force recommendation statement
Importance Cardiovascular disease (CVD) is the most common cause of death among
adults in the United States. Treatment to prevent CVD events by modifying risk factors is …
adults in the United States. Treatment to prevent CVD events by modifying risk factors is …
Cardiovascular risk and statin eligibility of young adults after an MI: partners YOUNG-MI registry
Background: Despite significant progress in primary prevention, the rate of MI has not
declined in young adults. Objectives: The purpose of this study was to evaluate statin …
declined in young adults. Objectives: The purpose of this study was to evaluate statin …
[HTML][HTML] Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
MF Van Stee, AA de Graaf, AK Groen - Cardiovascular diabetology, 2018 - Springer
Patients with diabetes type 2 have an increased risk for cardiovascular disease and
commonly use combination therapy consisting of the anti-diabetic drug metformin and a …
commonly use combination therapy consisting of the anti-diabetic drug metformin and a …
Screening for peripheral artery disease and cardiovascular disease risk assessment with the ankle-brachial index: US preventive services task force recommendation …
Importance Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the lower
limbs. It can impair walking and, in severe cases, can lead to tissue loss, infection, and …
limbs. It can impair walking and, in severe cases, can lead to tissue loss, infection, and …