Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …

The discovery of the central role played by the protein alpha-synuclein in Parkinson's
disease and other Lewy body brain disorders has had a great relevance in the …

Studies in the last decade have suggested the association of both neuroinflammatory
processes and immune responses in Parkinson disease (PD) pathology. PD pathology is …

Parkinson's disease (PD) is one of the synucleinopathies spectrum of disorders typified by
the presence of intraneuronal protein inclusions. It is primarily composed of misfolded and …

Traditionally neurological diseases have been classified, on the basis of their pathogenesis,
into vascular, degenerative, inflammatory and traumatic diseases. Examples of the main …

Iron is essential for cellular development and maintenance of multiple physiological
processes in the central nervous system. The disturbance of its homeostasis leads to …

It is now increasingly appreciated that glial cells play a critical role in the regulation of iron
homeostasis. Impairment of these properties might lead to dysfunction of iron metabolism …

Alpha-synuclein oligomers (α-synOs) are emerging as crucial factors in the pathogenesis of
synucleinopathies. Although the connection between neuroinflammation and α-syn still …

Mitochondria are exceptionally primed to play a key role in neuronal cell survival since they
are involved in energy production and function as the metabolic center of cells. Several …

Glial activation and neuroinflammation contribute to pathogenesis of neurodegenerative
diseases, linked to neuron loss and dysfunction. α‐Synuclein (α‐syn), as a metabolite of …