Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed,
even before any of the usual morphological correlates of pre-malignancy are recognizable …

The tumor microenvironment is a dynamic landscape in which the physical and mechanical
properties evolve dramatically throughout cancer progression. These changes are driven by …

Cancer has been characterized as a genetic disease, associated with mutations that cause
pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the …

Solid tumors are characterized by an abnormal stroma that contributes to the development of
biomechanical abnormalities in the tumor microenvironment. In particular, these …

During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …

Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect promotes nano …

Super-resolution imaging methods promote tissue characterization beyond the spatial
resolution limits of the devices and bridge the gap between histopathological analysis and …

The tumor microenvironment (TME) is a key factor regulating tumor cell invasion and
metastasis. The effects of biochemical factors such as stromal cells, immune cells, and …

Increasing evidence shows that mechanical stresses are critical in regulating cell functions,
fate, and diseases. However, no methods exist that can quantify isotropic compressive …

Caveolae are small invaginated pits that function as dynamic mechanosensors to buffer
tension variations at the plasma membrane. Here we show that under mechanical stress, the …