Neuroligins (NLs) are critical for synapse formation and function. NL3 R451C is an autism-
associated mutation. NL3 R451C knockin (KI) mice exhibit autistic behavioral abnormalities …

Increasing evidence suggests that the gut microbiota plays a key role in the central nervous
system (CNS), and alterations of the gut microbiota composition due to environmental …

Schizophrenia is a severely debilitating neurodevelopmental disorder. Establishing a causal
link between circuit dysfunction and particular behavioral traits that are relevant to …

E3 ubiquitin ligase (UBE3A) levels in the brain need to be tightly regulated, as loss of
functional UBE3A protein is responsible for the severe neurodevelopmental disorder …

Rapid plasticity of layer (L) 2/3 inhibitory circuits is an early step in sensory cortical map
plasticity, but its cellular basis is unclear. We show that, in mice of either sex, 1 d whisker …

Hippocampal GABA ergic interneurons are crucial for cortical network function and have
been implicated in psychiatric disorders. We show here that Neuregulin 3 (Nrg3), a relatively …

Gamma oscillations within the cerebral cortex and hippocampus are associated with
cognitive processes, including attention, sensory perception, and memory formation; a deficit …

Understanding the mechanisms of neurodegeneration is crucial for development of
therapies to treat neurological disorders. S100 proteins are extensively expressed in the …

Neurotrophic factor NRG1 and its receptor ErbB4 play a role in GABAergic circuit assembly
during development. ErbB4 null mice possess fewer interneurons, have decreased GABA …

Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited syndrome caused by
mutations in the leucine-rich glioma inactivated 1 (LGI1) gene. It is known that glutamatergic …