Mitochondrial metabolism and cancer
Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …
and anabolic growth in cancer cells. Although such a view has been instrumental for the …
RNA N6-methyladenosine modification in cancers: current status and perspectives
Abstract N 6-methyladenosine (m6A), the most abundant internal modification in eukaryotic
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …
[PDF][PDF] Machine learning identifies stemness features associated with oncogenic dedifferentiation
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …
[HTML][HTML] Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML
CD DiNardo, EM Stein, S de Botton… - … England Journal of …, 2018 - Mass Medical Soc
Background Mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) occur in 6 to
10% of patients with acute myeloid leukemia (AML). Ivosidenib (AG-120) is an oral, targeted …
10% of patients with acute myeloid leukemia (AML). Ivosidenib (AG-120) is an oral, targeted …
[PDF][PDF] R-2HG exhibits anti-tumor activity by targeting FTO/m6A/MYC/CEBPA signaling
Summary R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate
dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here …
dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here …
Ten principles of heterochromatin formation and function
RC Allshire, HD Madhani - Nature reviews Molecular cell biology, 2018 - nature.com
Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …
particular genomic domains with specific functional properties. The capacity of …
The key role of epigenetics in human disease prevention and mitigation
AP Feinberg - New England Journal of Medicine, 2018 - Mass Medical Soc
Epigenetics in Disease Prevention and Mitigation Epigenetics is the regulation of gene
expression through alterations in DNA or associated factors (other than the DNA sequence) …
expression through alterations in DNA or associated factors (other than the DNA sequence) …
Discovery of AG-120 (Ivosidenib): a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers
J Popovici-Muller, RM Lemieux, E Artin… - ACS medicinal …, 2018 - ACS Publications
Somatic point mutations at a key arginine residue (R132) within the active site of the
metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain of function in …
metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain of function in …
[PDF][PDF] Biological role and therapeutic potential of IDH mutations in cancer
Hotspot mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …
(IDH2) occur in a variety of myeloid malignancies and solid tumors. Mutant IDH proteins …
Protein moonlighting: what is it, and why is it important?
CJ Jeffery - … transactions of the Royal Society B …, 2018 - royalsocietypublishing.org
Members of the GroEL/HSP60 protein family have been studied for many years because of
their critical roles as ATP-dependent molecular chaperones, so it might come as a surprise …
their critical roles as ATP-dependent molecular chaperones, so it might come as a surprise …