Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …

Here we use deep sequencing to identify sources of variation in mRNA splicing in the
dorsolateral prefrontal cortex (DLPFC) of 450 subjects from two aging cohorts. Hundreds of …

Alzheimer's disease (AD) affects half the US population over the age of 85 and is universally
fatal following an average course of 10 years of progressive cognitive disability. Genetic and …

Abstract Background Epstein-Barr virus (EBV) is ubiquitously associated with
nasopharyngeal carcinoma (NPC). EBV encodes two groups of microRNAs (miRNAs) which …

Abstract GJA1 (connexin43) has been predicted as the top key driver of an astrocyte
enriched subnetwork associated with Alzheimer's disease (AD). In this study, we …

Revealing the relationship between dysfunctional genes in blood and brain tissues from
patients with Alzheimer's Disease (AD) will help us to understand the pathology of this …

Background Most neurodegenerative diseases associated with protein aggregation are
hallmarked by activation of astrocytes. However, how astrocytes are activated or which …

Alzheimer's disease (AD) is a neurodegenerative disorder contributing to rapid decline in
cognitive function and ultimately dementia. Most cases of AD occur in elderly and later …

Background Cerebral amyloidosis, neuroinflammation, and tauopathy are key features of
Alzheimer's disease (AD), but interactions among these features remain poorly understood …

One of important aspects of development of Alzheimer's disease is degeneration of septal
cholinergic neurons that innervate the hippocampus. We took advantage of widely used …