Impacts of genome-wide analyses on our understanding of human herpesvirus diversity and evolution

DW Renner, ML Szpara - Journal of virology, 2018 - Am Soc Microbiol
Until fairly recently, genome-wide evolutionary dynamics and within-host diversity were
more commonly examined in the context of small viruses than in the context of large double …

A new era in cytomegalovirus vaccinology: considerations for rational design of next-generation vaccines to prevent congenital cytomegalovirus infection

CS Nelson, BC Herold, SR Permar - NPJ vaccines, 2018 - nature.com
Human cytomegalovirus (HCMV), a member of the beta-herpesvirus family, is the most
common cause of congenital infection worldwide as well as an important cause of morbidity …

Defining the transcriptional landscape during cytomegalovirus latency with single-cell RNA sequencing

M Shnayder, A Nachshon, B Krishna, E Poole… - MBio, 2018 - Am Soc Microbiol
Primary infection with human cytomegalovirus (HCMV) results in a lifelong infection due to
its ability to establish latent infection, with one characterized viral reservoir being …

[HTML][HTML] HCMV-encoded NK modulators: lessons from in vitro and in vivo genetic variation

M Patel, VM Vlahava, SK Forbes, CA Fielding… - Frontiers in …, 2018 - frontiersin.org
Human cytomegalovirus (HCMV) is under constant selective pressure from the immune
system in vivo. Study of HCMV genes that have been lost in the absence of, or genetically …

Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks

NA Bryant, GS Wilkie, CA Russell… - Transboundary and …, 2018 - Wiley Online Library
Summary Equine herpesvirus 1 (EHV‐1) causes respiratory disease, abortion, neonatal
death and neurological disease in equines and is endemic in most countries. The viral …

Expression levels of glycoprotein O (gO) vary between strains of human cytomegalovirus, influencing the assembly of gH/gL complexes and virion infectivity

L Zhang, M Zhou, R Stanton, J Kamil… - Journal of …, 2018 - Am Soc Microbiol
The tropism of human cytomegalovirus (HCMV) is influenced by the envelope glycoprotein
complexes gH/gL/gO and gH/gL/UL128-131. During virion assembly, gO and the UL128 …

Whole genome diversity of inherited chromosomally integrated HHV-6 derived from healthy individuals of diverse geographic origin

M Telford, A Navarro, G Santpere - Scientific Reports, 2018 - nature.com
Human herpesviruses 6-A and-B (HHV-6A, HHV-6B) are ubiquitous in human populations
worldwide. These viruses have been associated with several diseases such as multiple …

Nanopore sequencing and full genome de novo assembly of human cytomegalovirus TB40/E reveals clonal diversity and structural variations

T Karamitros, B van Wilgenburg, M Wills, P Klenerman… - BMC genomics, 2018 - Springer
Background Human cytomegalovirus (HCMV) has a double-stranded DNA genome of
approximately 235 Kbp that is structurally complex including extended GC-rich repeated …

A prominent role of the human cytomegalovirus UL8 glycoprotein in restraining proinflammatory cytokine production by myeloid cells at late times during infection

N Pérez-Carmona, P Martínez-Vicente, D Farré… - Journal of …, 2018 - Am Soc Microbiol
Human cytomegalovirus (HCMV) persistence in infected individuals relies on a plethora of
mechanisms to efficiently reduce host immune responses. To that end, HCMV uses a variety …

[HTML][HTML] Genomic, recombinational and phylogenetic characterization of global feline herpesvirus 1 isolates

AC Lewin, AW Kolb, GJ McLellan, E Bentley… - Virology, 2018 - Elsevier
Feline herpes virus type 1 (FHV-1) is widely considered to be the leading cause of ocular
disease in cats and has been implicated in upper respiratory tract infections. Little, however …