Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

Significance: A growing body of clinical and experimental evidence has challenged the
traditional understanding that only the adaptive immune system can mount immunological …

Background: Bisphenol A (BPA) is an endocrine disrupting chemical widely used in the
manufacture of polycarbonate plastic and epoxy resin to produce a multitude of consumer …

The ovarian hormones estrogen and progesterone are master regulators of the development
and function of a broad spectrum of human tissues, including the breast, reproductive and …

Epigenetic modifications on chromatin are most commonly thought to be involved in the
transcriptional regulation of gene expression. Due to their dependency on small-molecule …

In recent years, anti-tumor immunotherapy has shown promising results, and immune-
oncology is now emerging as the fourth major wave in the treatment of tumors after …

Alzheimer's disease (AD) is the most important neurodegenerative disorder in Western
countries. Pathological phenotypes of neurodegeneration result from a combination of …

Recent research in psychiatric genetics has led to a move away from simple diathesis-stress
models to more complex models of psychopathology incorporating a focus on gene …

Cerebrovascular and neurodegenerative disorders affect one billion people around the
world and result from a combination of genomic, epigenomic, metabolic, and environmental …

Nowadays advanced mass spectrometry techniques make the identification of protein
posttranslational modifications (PTMs) much easier than ever before. A series of proteomic …