BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Phenolics, which are secondary metabolites of plants, exhibit remarkable bioactivities. In this
contribution, we have focused on their protective effect against chronic diseases rather than …

The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …

Sirtuins are NAD+-dependent protein deacylases/ADP-ribosyltransferases that have
emerged as candidate targets for new therapeutics to treat metabolic disorders and other …

Recent evidence shows that resveratrol (RSV) may ameliorate high-glucose-induced
cardiac oxidative stress, mitochondrial dysfunction and myocardial fibrosis in diabetes …

Reducing oxidative stress is a crucial therapeutic strategy for ameliorating diabetic
myocardial ischemia/reperfusion (MI/R) injury. Honokiol (HKL) acts as an effective …

Silent information regulator 1 (SIRT1) exerts neuroprotection in many neurodegenerative
diseases. However, it is not clear if SIRT1 has protective effects after intracerebral …