Microbial tryptophan catabolites in health and disease

HM Roager, TR Licht - Nature communications, 2018 - nature.com
Accumulating evidence implicates metabolites produced by gut microbes as crucial
mediators of diet-induced host-microbial cross-talk. Here, we review emerging data …

Best practices for analysing microbiomes

R Knight, A Vrbanac, BC Taylor, A Aksenov… - Nature Reviews …, 2018 - nature.com
Complex microbial communities shape the dynamics of various environments, ranging from
the mammalian gastrointestinal tract to the soil. Advances in DNA sequencing technologies …

Structure and function of the global topsoil microbiome

M Bahram, F Hildebrand, SK Forslund, JL Anderson… - Nature, 2018 - nature.com
Soils harbour some of the most diverse microbiomes on Earth and are essential for both
nutrient cycling and carbon storage. To understand soil functioning, it is necessary to model …

[HTML][HTML] Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features

N Zmora, G Zilberman-Schapira, J Suez, U Mor… - Cell, 2018 - cell.com
Empiric probiotics are commonly consumed by healthy individuals as means of life quality
improvement and disease prevention. However, evidence of probiotic gut mucosal …

[HTML][HTML] Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT

J Suez, N Zmora, G Zilberman-Schapira, U Mor… - Cell, 2018 - cell.com
Probiotics are widely prescribed for prevention of antibiotics-associated dysbiosis and
related adverse effects. However, probiotic impact on post-antibiotic reconstitution of the gut …

Current understanding of the human microbiome

JA Gilbert, MJ Blaser, JG Caporaso, JK Jansson… - Nature medicine, 2018 - nature.com
Our understanding of the link between the human microbiome and disease, including
obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding …

Extensive impact of non-antibiotic drugs on human gut bacteria

L Maier, M Pruteanu, M Kuhn, G Zeller, A Telzerow… - Nature, 2018 - nature.com
A few commonly used non-antibiotic drugs have recently been associated with changes in
gut microbiome composition, but the extent of this phenomenon is unknown. Here, we …

MetaWRAP—a flexible pipeline for genome-resolved metagenomic data analysis

GV Uritskiy, J DiRuggiero, J Taylor - Microbiome, 2018 - Springer
Background The study of microbiomes using whole-metagenome shotgun sequencing
enables the analysis of uncultivated microbial populations that may have important roles in …

Gut microbiota in the pathogenesis of inflammatory bowel disease

A Nishida, R Inoue, O Inatomi, S Bamba… - Clinical journal of …, 2018 - Springer
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a
chronic and relapsing inflammatory disorder of the intestine. Although its incidence is …

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

V Gopalakrishnan, CN Spencer, L Nezi, A Reuben… - Science, 2018 - science.org
Preclinical mouse models suggest that the gut microbiome modulates tumor response to
checkpoint blockade immunotherapy; however, this has not been well-characterized in …