Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

During adolescence, both rodent and human studies have revealed dynamic changes in the
developmental trajectories of corticolimbic structures, which are known to contribute to the …

The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …

The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term
synaptic plasticity in brain regions involved in various neural functions ranging from action …

Mental disorders have a high prevalence compared with many other health conditions and
are the leading cause of disability worldwide. Several studies performed in the last years …

Exposure to a traumatic event may result in the development of post-traumatic stress
disorder (PTSD). Endocannabinoids are crucial modulators of the stress response, interfere …

Enhancing endogenous cannabinoid (eCB) signaling has been considered as a potential
strategy for the treatment of stress-related conditions. Fatty acid amide hydrolase (FAAH) …

Activating the endocannabinoid system has become a major focus in the search for novel
therapeutics for anxiety and deficits in fear extinction, two defining features of PTSD. We …

Rationale The endocannabinoid neurotransmitter, anandamide, has been implicated in the
central modulation of stress responses. Previous animal experiments have shown that …

The endocannabinoid system is an increasingly recognised pharmacological target for
treating stress and anxiety disorders, including post-traumatic stress disorder (PTSD) …