Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been
profoundly revised following recent advances in the understanding of its pathophysiology. In …

Alterations in barrier function are associated with a number of skin diseases, including
xerosis, atopic dermatitis, and psoriasis. Urea, a component of the natural moisturizing factor …

Psoriasis is a chronic inflammatory skin condition affecting diverse racial/ethnic groups
throughout the world. Large population-based studies suggest that psoriasis occurs most …

Background Psoriasis is a chronic inflammatory autoimmune skin disorder. Several studies
suggested psoriasis to be a complex multifactorial disease, but the exact triggering factor is …

Background Mutations in keratin proteins have been vastly associated with a wide array of
genodermatoses; however, mutations of keratins in psoriasis have not been fully …

The role of interleukin-23 is crucial in the pathogenesis of psoriasis, and IL23A, IL12B and
IL23R genetic variants have been associated with the disease in genome-wide association …

Abstract Background CCHCR1 (Coiled-Coil α-Helical Rod protein 1) is a putative psoriasis
candidate gene with the risk alleles CCHCR1* WWCC and* Iso3, the latter inhibiting the …

Genotype imputation is now routinely performed in genomic analysis. Reference panel size,
that is, the number of haplotypes in the reference panel, has been well established to be one …

Background Recent studies have revealed that DNA methylation (DNAm) could modulate
gene expression in psoriasis (Ps). However, the relationship between whole-genome DNAm …

Medical genetics is the newest cutting-edge discipline that focuses on solving medical
problems using genetics knowledge and methods. In China, medical genetics research …