Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …

Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …

Background: DNA methylation-based patterns of biological aging, known as epigenetic age
acceleration, are predictive of all-cause mortality, but little is known about their association …

Purpose of Review DNA methylation-based aging biomarkers are valuable tools for
evaluating the aging process from a molecular perspective. These epigenetic aging …

Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …

Survival predictors are of potential use for informing on biological age and targeting
prevention of aging-related morbidity. We assessed associations of 2 novel methylomic …

Cancer is largely an aging disease. Accelerated biological aging may be the strongest
predictor of cancer and other chronic disease risks. In the absence of reliable and …

Background DNA methylation (DNAm) age was found to be an indicator for all-cause
mortality, cancer incidence, and longevity, but no study has involved in the associations of …