Heart in space: effect of the extraterrestrial environment on the cardiovascular system

RL Hughson, A Helm, M Durante - Nature Reviews Cardiology, 2018 - nature.com
National space agencies and private corporations aim at an extended presence of humans
in space in the medium to long term. Together with currently suboptimal technology …

iPSCs-based generation of vascular cells: reprogramming approaches and applications

D Klein - Cellular and Molecular Life Sciences, 2018 - Springer
Recent advances in the field of induced pluripotent stem cells (iPSCs) research have
opened a new avenue for stem cell-based generation of vascular cells. Based on their …

The role of vascular smooth muscle cells in the physiology and pathophysiology of blood vessels

L Bacakova, M Travnickova, E Filova… - Muscle Cell and …, 2018 - books.google.com
Vascular smooth muscle cells (VSMCs) play important roles not only in the physiological
functions of the blood vessels, such as vasoconstriction, vasodilatation and extracellular …

Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

B Liu, M Pjanic, T Wang, T Nguyen… - The American Journal of …, 2018 - cell.com
Coronary artery disease (CAD) is the leading cause of death globally. Genome-wide
association studies (GWASs) have identified more than 95 independent loci that influence …

Distinct cellular mechanisms underlie smooth muscle turnover in vascular development and repair

U Roostalu, B Aldeiri, A Albertini, N Humphreys… - Circulation …, 2018 - Am Heart Assoc
Rationale: Vascular smooth muscle turnover has important implications for blood vessel
repair and for the development of cardiovascular diseases, yet lack of specific transgenic …

LncRNA UCA1 sponges miR-26a to regulate the migration and proliferation of vascular smooth muscle cells

S Tian, Y Yuan, Z Li, M Gao, Y Lu, H Gao - Gene, 2018 - Elsevier
Background Recent studies have shown that the long non-coding RNA urothelial carcinoma-
associated (UCA1) plays a key role in cardiovascular injury. However, the potential …

Smooth muscle: a stiff sculptor of epithelial shapes

JM Jaslove, CM Nelson - Philosophical Transactions of …, 2018 - royalsocietypublishing.org
Smooth muscle is increasingly recognized as a key mechanical sculptor of epithelia during
embryonic development. Smooth muscle is a mesenchymal tissue that surrounds the …

Vascular extracellular matrix and fibroblasts-coculture directed differentiation of human mesenchymal stem cells toward smooth muscle-like cells for vascular tissue …

N Li, H Sanyour, T Remund, P Kelly, Z Hong - Materials Science and …, 2018 - Elsevier
Construction of an artificial vascular graft is widely considered a promising strategy in
vascular tissue engineering. However, limited sources of functional vascular smooth muscle …

Development of molecular therapies for venous malformations

J Kangas, M Nätynki, L Eklund - Basic & Clinical Pharmacology …, 2018 - Wiley Online Library
Vascular anomalies are localized defects of morphogenesis that can affect lymphatic and
blood vessels. They are generally called birthmarks, typically observed soon after birth and …

Vascular stem/progenitor cell migration and differentiation in atherosclerosis

B Yu, Q Chen, A Le Bras, L Zhang… - Antioxidants & redox …, 2018 - liebertpub.com
Significance: Atherosclerosis is a major cause for the death of human beings, and it takes
place in large-and middle-sized arteries. The pathogenesis of the disease has been widely …