The Lancet Commission on global mental health and sustainable development

V Patel, S Saxena, C Lund, G Thornicroft, F Baingana… - The lancet, 2018 - thelancet.com
Executive summary The Sustainable Development Goals (SDGs) represent an exponential
advance from the Millennium Development Goals, with a substantially broader agenda …

[PDF][PDF] Predictive processing: a canonical cortical computation

GB Keller, TD Mrsic-Flogel - Neuron, 2018 - cell.com
This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

MJ Gandal, P Zhang, E Hadjimichael, RL Walker… - Science, 2018 - science.org
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …

All for one and one for all: Mental disorders in one dimension

A Caspi, TE Moffitt - American Journal of Psychiatry, 2018 - Am Psychiatric Assoc
In both child and adult psychiatry, empirical evidence has now accrued to suggest that a
single dimension is able to measure a person's liability to mental disorder, comorbidity …

Comprehensive functional genomic resource and integrative model for the human brain

D Wang, S Liu, J Warrell, H Won, X Shi, FCP Navarro… - Science, 2018 - science.org
INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

M Li, G Santpere, Y Imamura Kawasawa, OV Evgrafov… - Science, 2018 - science.org
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …

[HTML][HTML] Microglia and beyond: innate immune cells as regulators of brain development and behavioral function

KM Lenz, LH Nelson - Frontiers in immunology, 2018 - frontiersin.org
Innate immune cells play a well-documented role in the etiology and disease course of
many brain-based conditions, including multiple sclerosis, Alzheimer's disease, traumatic …

Gamma oscillations as a biomarker for major depression: an emerging topic

PJ Fitzgerald, BO Watson - Translational psychiatry, 2018 - nature.com
Identifying biomarkers for major depression is of high importance for improving diagnosis
and treatment of this common and debilitating neuropsychiatric disorder, as the field seeks …

[PDF][PDF] Astrocyte-secreted chordin-like 1 drives synapse maturation and limits plasticity by increasing synaptic GluA2 AMPA receptors

E Blanco-Suarez, TF Liu, A Kopelevich, NJ Allen - Neuron, 2018 - cell.com
In the developing brain, immature synapses contain calcium-permeable AMPA glutamate
receptors (AMPARs) that are subsequently replaced with GluA2-containing calcium …

Recent advances in the genetics of schizophrenia

D Avramopoulos - Complex Psychiatry, 2018 - karger.com
The last decade brought tremendous progress in the field of schizophrenia genetics. As a
result of extensive collaborations and multiple technological advances, we now recognize …