Despite the great research effort placed during the last decades in HIV-1 study, still some
aspects of its replication cycle remain unknown. All this powerful research has succeeded in …

Mammalian cells have evolved several mechanisms to prevent or block lentiviral infection
and spread. Among the innate immune mechanisms, the signaling cascade triggered by …

In the present work, we described the synthesis, antiviral profiles and metabolic stability in
human plasma of compound 6, a potential carbonate prodrug of HIV-1 NNRTI drug …

New immunogens that elicit the production of broadly neutralizing antibodies (bNAbs) are
needed to prevent and control HIV-1 epidemic. However, their induction by vaccination is …

A falha imunológica em pacientes portadores do Vírus da Imunodeficiência Adquirida (HIV)
decorre da não recuperação de células T CD4+, mesmo nos indivíduos que apresentam …

Acquired Immune Deficiency Syndrome (AIDS) is the most serious stage of Human
Immunodeficiency Virus (HIV) infection. The combinatorial Anti-Retroviral Therapy (cART) is …

A Síndrome da Imunodeficiência Adquirida (AIDS) é consequência de uma infecção
causada pelo Vírus da Imunodeficiência Humana (HIV), que leva a destruição progressiva …

Background: Cellular and anatomical reservoirs of HIV remain the primary challenge
towards viral eradication. The lungs are important but relatively understudied anatomical …

Nucleocapsid protein (NC) plays crucial roles in HIV-1 life cycle through its nucleic acid (NA)
chaperoning property that involves recognition of it's Trp37 residue with a Guanine residue …

Retroviruses include two subfamilies, orthoretrovirinae and spumaretrovirinae. The human
immunodeficiency virus 1 (HIV-1) belongs to the orthoretrovirinae subfamily and is the …