The process of finding new therapeutic indications for currently used drugs, defined as
'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an …

Osteoarthritis (OA) is the most common joint disease and a leading cause for impaired
function and disability with significant treatment costs and socio-economic burden. Despite …

Objective Cardiovascular disease (CVD) is the leading cause of mortality in patients with
rheumatoid arthritis (RA). Hydroxychloroquine (HCQ) has been shown to improve survival …

This is the first study to investigate the hepatoprotective effect of CQ on acute liver injury
caused by carbon tetrachloride (CCl4) in a murine model and the underlying molecular …

Inflammation is a major contributor to the pathogenesis of ischemic acute kidney injury (AKI),
which complicates the post-operative outcomes of large numbers of hospitalized surgical …

Background and Objective: Rheumatoid arthritis (RA) is a predominant inflammatory
autoimmune disorder. The incidence and prevalence of RA is increasing with considerable …

Organic anion transporting polypeptides (OATP) 1B1 and OATP1B3 are important hepatic
transporters that mediate the uptake of many clinically important drugs, including statins from …

The relapse rate in antiphospholipid syndrome (APS) remains high, ie around 20%–21% at
5 years in thrombotic APS and 20–28% in obstetrical APS [2, 3]. Hydroxychloroquine (HCQ) …

An appreciation of the functional properties of the cytoplasmic fatty acid binding protein 4
(FABP4) has advanced with the recent demonstration that an extracellular form secreted by …

Hydroxychloroquine: balancing the need to maintain therapeut... : Current Opinion in
Rheumatology Hydroxychloroquine: balancing the need to maintain therapeutic levels with …