Objectives: Several randomized controlled trials (RCTs) on the use of probiotics to reduce
morbidity and mortality in preterm infants have provided inconsistent results. Although meta …

Newborn infants are at a high risk for infection due to an under-developed immune system,
and human milk has been shown to exhibit substantial anti-infective properties that serve to …

Objectives To determine whether antibiotic use in the first 14 postnatal days in preterm, very
low birth weight (birth weight of≤ 1500 g) infants is associated with risk after 14 days of age …

Background: Currently, prophylactic use of drugs to promote a healthy gut microbiota and
immune system in preterm infants is hot debated, among which lactoferrin is a promising …

Supplementation with probiotics in preterm infants reduces necrotizing enterocolitis and
sepsis. Bovine lactoferrin is a promising supplement that may further reduce disease …

Objective To investigate whether exposure to inhibitors of gastric acidity, such as H2
blockers or proton pump inhibitors, can independently increase the risk of infections in very …

Enteral feeding and composition play a chief role in the prevention and treatment of
necrotizing enterocolitis (NEC). In the face of decades of research on this fatal disease, the …

Lactoferrin is an abundant glycoprotein in bovine milk that has immunomodulatory effects on
human cells. Bovine lactoferrin (LF) binds lipopolysaccharides (LPS) with high affinity and is …

Background Lactobacillus casei (L. casei) is well known for its probiotic property in human
and animals. Lactoferricin (Lfcin) polypeptide can effectively modulate host immune …

Mesenteric adipose tissue hyperplasia is a hallmark of Crohn's disease (CD). Recently, we
showed that mesenteric adipose-derived stromal cells (ADSCs) from CD, ulcerative colitis …