CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011–2015
QT Ostrom, H Gittleman, G Truitt, A Boscia… - Neuro …, 2018 - academic.oup.com
Background CBTRUS is a unique professional research organization that focuses
exclusively on providing high-quality statistical data on the population-based incidence of …
exclusively on providing high-quality statistical data on the population-based incidence of …
[HTML][HTML] Natural products for drug discovery in the 21st century: innovations for novel drug discovery
NE Thomford, DA Senthebane, A Rowe… - International journal of …, 2018 - mdpi.com
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …
pathological conditions have been treated using plant-derived medicines. These medicines …
cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”
The World Health Organization (WHO) central nervous system tumor classification
represents the primary source of updates on diagnostic classes, grades and criteria [17] …
represents the primary source of updates on diagnostic classes, grades and criteria [17] …
[HTML][HTML] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics
J Liu, T Lichtenberg, KA Hoadley, LM Poisson… - Cell, 2018 - cell.com
Summary For a decade, The Cancer Genome Atlas (TCGA) program collected
clinicopathologic annotation data along with multi-platform molecular profiles of more than …
clinicopathologic annotation data along with multi-platform molecular profiles of more than …
[HTML][HTML] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …
[HTML][HTML] Genomic and molecular landscape of DNA damage repair deficiency across the cancer genome atlas
TA Knijnenburg, L Wang, MT Zimmermann… - Cell reports, 2018 - cell.com
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view …
response. We systematically analyzed somatic alterations to provide a comprehensive view …
[HTML][HTML] Genomic and functional approaches to understanding cancer aneuploidy
Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal
characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas …
characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas …
[HTML][HTML] R-2HG exhibits anti-tumor activity by targeting FTO/m6A/MYC/CEBPA signaling
Summary R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate
dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here …
dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here …
Predicting cancer outcomes from histology and genomics using convolutional networks
Cancer histology reflects underlying molecular processes and disease progression and
contains rich phenotypic information that is predictive of patient outcomes. In this study, we …
contains rich phenotypic information that is predictive of patient outcomes. In this study, we …
WHO 2016 Classification of gliomas
P Wesseling, D Capper - Neuropathology and applied …, 2018 - Wiley Online Library
Gliomas are the most frequent intrinsic tumours of the central nervous system and
encompass two principle subgroups: diffuse gliomas and gliomas showing a more …
encompass two principle subgroups: diffuse gliomas and gliomas showing a more …