Prior to the sequencing of the human genome, it was presumed that most of the DNA coded
for proteins. However, with the advent of next-generation sequencing, it has now been …

The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …

Summary N 6-methyladenosine (m 6 A) and N 6, 2′-O-dimethyladenosine (m 6 Am) are
abundant mRNA modifications that regulate transcript processing and translation. The role …

Neurons localize mRNAs near synapses where their translation can be regulated by
synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …

Abstract N 6-methyladenosine (m6A) is the most prevalent internal modification of
mammalian messenger RNAs (mRNAs) and long non-coding RNAs. The biological …

Maternal immune activation (MIA) via infection during pregnancy is known to increase risk
for autism spectrum disorder (ASD). However, it is unclear how MIA disrupts fetal brain gene …

Mutations in the fragile X mental retardation 1 gene (FMR1) cause the most common
inherited human autism spectrum disorder. FMR1 influences messenger RNA (mRNA) …

Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to
the functional deficiency of the fragile X mental retardation protein (FMRP), an RNA-binding …

In mammals, gene silencing by the RNA-induced silencing complex (RISC) is a well-
understood cytoplasmic posttranscriptional gene regulatory mechanism. Here, we show that …

Research in the past decades has unfolded the multifaceted role of Fragile X mental
retardation protein (FMRP) and how its absence contributes to the pathophysiology of …