Current progress on antioxidants incorporating the pyrazole core

VLM Silva, J Elguero, AMS Silva - European journal of medicinal chemistry, 2018 - Elsevier
The search of new antioxidants, as drugs candidates, is an active field of medicinal
chemistry. The synthesis of compounds with antioxidant potential has increased in recent …

Pyrazolone: a powerful synthon for asymmetric diverse derivatizations

S Liu, X Bao, B Wang - Chemical communications, 2018 - pubs.rsc.org
As a powerful synthon, pyrazolone has widely been exploited for the construction of various
chiral pyrazoles/pyrazolones which hold great potential in the development of …

Advances in spirocyclic hybrids: chemistry and medicinal actions

M Benabdallah, O Talhi, F Nouali… - Current Medicinal …, 2018 - ingentaconnect.com
The present review deals with the progress in medicinal chemistry of spirocyclic compounds,
a wider class of natural and synthetic organic molecules, defined as a hybrid of two …

[HTML][HTML] Design, synthesis, DFT, docking studies and ADME prediction of some new coumarinyl linked pyrazolylthiazoles: Potential standalone or adjuvant …

S Kumar, V Saini, IK Maurya, J Sindhu, M Kumari… - PloS one, 2018 - journals.plos.org
The control of antimicrobial resistance (AMR) seems to have come to a dead end. The major
consequences of the use and abuse of antibacterial drugs are the development of resistant …

Synthesis, spectral characterization and X-ray crystal structure studies of 3-(benzo [d][1, 3] dioxol-5-yl)-5-(3-methylthiophen-2-yl)-4, 5-dihydro-1H-pyrazole-1 …

K Kumara, AD Kumar, S Naveen, KA Kumar… - Journal of Molecular …, 2018 - Elsevier
Abstract A novel pyrazole derivative, 3-(benzo [d][1, 3] dioxol-5-yl)-5-(3-methylthiophen-2-yl)-
4, 5-dihydro-1H-pyrazole-1-carboxamide was synthesized and characterized by elemental …

Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity

ACC Aguiar, M Panciera… - Journal of medicinal …, 2018 - ACS Publications
We report the discovery of marinoquinoline (3 H-pyrrolo [2, 3-c] quinoline) derivatives as
new chemotypes with antiplasmodial activity. We evaluated their inhibitory activities against …

Ce (iii)-Containing tungstotellurate (vi) with a sandwich structure: an efficient Lewis acid–base catalyst for the condensation cyclization of 1, 3-diketones with …

GP Yang, SX Shang, B Yu, CW Hu - Inorganic Chemistry Frontiers, 2018 - pubs.rsc.org
A new Ce3+ modified Dawson-like polyoxometalate cluster (C2H8N) 12Na2 [H10 {Ce (H2O)
5} 2 (Te2W37O132)]· 39H2O was synthesized using pH and temperature-controlled one-pot …

Sunlight‐promoted Direct Irradiation of N‐centred Anion: The Photocatalyst‐free Synthesis of Pyrazoles in Water

T Zhang, Y Meng, J Lu, Y Yang, GQ Li… - Advanced Synthesis & …, 2018 - Wiley Online Library
A practical method through sunlight mediated annulation of α, β‐unsaturated hydrazones
has been developed for the synthesis of pyrazole. Based on the analysis of UV‐Vis …

Organocatalytic Enantioselective aza‐Friedel‐Crafts Reactions of Pyrazolinone Ketimines with Hydroxyindoles and Electron‐Rich Phenols

ZT Yang, WL Yang, L Chen, H Sun… - Advanced Synthesis & …, 2018 - Wiley Online Library
A variety of enantioenriched indole derivatives substituted in the benzene ring were
synthesised via an organocatalytic asymmetric aza‐Friedel‐Crafts reaction of pyrazolinone …

[HTML][HTML] Computational investigation of the structure and antioxidant activity of some pyrazole and pyrazolone derivatives

EA Orabi, MAA Orabi, MH Mahross… - Journal of Saudi …, 2018 - Elsevier
Pyrazoles and pyrazolones constitute a group of organic compounds that have various
medical applications such as antimicrobial, antipyretic, anti-inflammatory, antitumor and …