In both child and adult psychiatry, empirical evidence has now accrued to suggest that a
single dimension is able to measure a person's liability to mental disorder, comorbidity …

Adverse experiences in childhood and adolescence, defined as subjectively perceived
threats to the safety or security of the child's bodily integrity, family, or social structures, are …

An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

Purpose To review and synthesise prognostic indices that predict subsequent risk,
prescriptive indices that moderate treatment response, and mechanisms that underlie each …

Background Non-suicidal self-injury is being increasingly recognised as a prominent public
health concern. Identification of early and modifiable risk factors is necessary to advance the …

Background One third of patients with major depressive disorder (MDD) fail to respond to
currently available antidepressant medications. Inflammation may contribute to treatment …

Child maltreatment has well-documented long-term, adverse effects on mental health, but it
is not clear whether there are gender differences in these effects. We conducted a …

Empirical studies suggest that psychiatric disorders result from a complex interplay between
genetic and environmental factors. Most evidence for such gene-environment interaction …

Objective: Major depressive disorder is associated with an increased risk of mortality and
aging-related diseases. The authors examined whether major depression is associated with …

Background Gene-environment interaction contributes to the risks of psychiatric disorders.
Interactions between FKBP5 gene variants and early-life stress may enhance the risk not …