An ongoing technological revolution is continually improving our ability to carry out very high-
resolution studies of gene expression patterns. Current technology enables the global gene …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …

Upon fertilization, drastic chromatin reorganization occurs during preimplantation
development. However, the global chromatin landscape and its molecular dynamics in this …

Cells are the basic building blocks of organisms and each cell is unique. Single-cell RNA
sequencing has emerged as an indispensable tool to dissect the cellular heterogeneity and …

Single-cell RNASeq (scRNASeq) has emerged as a powerful method for quantifying the
transcriptome of individual cells. However, the data from scRNASeq experiments is often …

The emergence of form and function during mammalian embryogenesis is a complex
process that involves multiple regulatory levels. The foundations of the body plan are laid …

Single-cell profiling techniques create opportunities to delineate cell fate progression in
mammalian development. Recent studies have provided transcriptome data from human pre …

In the era of precision medicine, multi-omics approaches enable the integration of data from
diverse omics platforms, providing multi-faceted insight into the interrelation of these omics …

During the last decade, high‐throughput sequencing methods have revolutionized the entire
field of biology. The opportunity to study entire transcriptomes in great detail using RNA …