Viruses exploit the host and induce drastic metabolic changes to ensure an optimal
environment for replication and the production of viral progenies. In response, the host has …

Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a
deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the …

Sterile alpha motif and HD-domain–containing protein 1 (SAMHD1) blocks replication of
retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has …

Macrophages exhibit phenotypic heterogeneity under both physiological and pathological
conditions. Applications targeting M2-like tumor-associated macrophages (TAMs) improve …

We report that DNA damage induced by topoisomerase inhibitors, including etoposide
(ETO), results in a potent block to HIV‐1 infection in human monocyte‐derived macrophages …

Aicardi–Goutières syndrome (AGS) is an early‐onset, autoimmune and genetically
heterogeneous disorder with severe neurologic injury. Molecular studies have established …

Activation-induced deaminase (AID) initiates hypermutation of Ig genes in activated B cells
by converting C: G into U: G base pairs. G1-phase variants of uracil base excision repair …

Abstract The autoimmune disorder Aicardi-Goutières syndrome (AGS) is characterized by a
constitutive type I interferon response. SAMHD1 possesses both dNTPase and RNase …

Abstract Human SAMHD1 (hSAMHD1) is a retroviral restriction factor that blocks HIV-1
infection by depleting the cellular nucleotides required for viral reverse transcription …

Lentiviruses infect both dividing CD4+ T cells and nondividing myeloid cells, and the
infected myeloid cells serve as long-living viral reservoirs. Host sterile alpha motif–and …