Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of …

Y Wirz, MA Meier, L Bouadma, CE Luyt, M Wolff… - Critical care, 2018 - Springer
Background The clinical utility of serum procalcitonin levels in guiding antibiotic treatment
decisions in patients with sepsis remains unclear. This patient-level meta-analysis based on …

Biomarkers in sepsis

TSR Van Engelen, WJ Wiersinga… - Critical care …, 2018 - criticalcare.theclinics.com
Sepsis is characterized by complex pathophysiology and heterogeneous phenotypes of
affected patients regarding their symptoms, response to treatment, and outcomes. At present …

Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis

P Schuetz, Y Wirz, R Sager, M Christ-Crain… - The Lancet infectious …, 2018 - thelancet.com
Summary Background In February, 2017, the US Food and Drug Administration approved
the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute …

Low-picomolar, label-free procalcitonin analytical detection with an electrolyte-gated organic field-effect transistor based electronic immunosensor

P Seshadri, K Manoli, N Schneiderhan-Marra… - Biosensors and …, 2018 - Elsevier
Herein a label-free immunosensor based on electrolyte-gated organic field-effect transistor
(EGOFET) was developed for the detection of procalcitonin (PCT), a sepsis marker …

Sepsis in pregnancy and the puerperium

CEG Burlinson, D Sirounis, KR Walley… - International journal of …, 2018 - Elsevier
Sepsis remains a leading cause of maternal morbidity and mortality. Recognition and
treatment of maternal sepsis are often delayed due to the physiological adaptations of …

[HTML][HTML] Procalcitonin-guided antibiotic therapy: an expert consensus

M Bartoletti, M Antonelli, FAB Blasi… - Clinical Chemistry and …, 2018 - degruyter.com
Background: Procalcitonin (PCT) is a useful biomarker of bacterial infection and its use is
associated to reduced duration of antibiotic therapy in the setting of intensive care medicine …

[HTML][HTML] Pentraxin-3, procalcitonin and lactate as prognostic markers in patients with sepsis and septic shock

C Hu, Y Zhou, C Liu, Y Kang - Oncotarget, 2018 - ncbi.nlm.nih.gov
The purpose of this study was to confirm the prognostic value of pentraxin-3 (PTX3),
procalcitonin (PCT) and lactate in patients with severe infections requiring ICU management …

Plasma procalcitonin concentrations predict organ dysfunction and outcome in dogs with sepsis

R Troia, M Giunti, R Goggs - BMC veterinary research, 2018 - Springer
Background Procalcitonin (PCT) is a valuable prognostic biomarker in human sepsis that is
predictive of organ dysfunction, septic shock and mortality. Data on PCT in dogs is limited …

Real-world use of procalcitonin and other biomarkers among sepsis hospitalizations in the United States: A retrospective, observational study

E Gluck, HB Nguyen, K Yalamanchili, M McCusker… - PloS one, 2018 - journals.plos.org
Background Sepsis management guidelines endorse use of biomarkers to support clinical
assessment and treatment decisions in septic patients. The impact of biomarkers on …

Procalcitonin kinetics after burn injury and burn surgery in septic and non-septic patients–a retrospective observational study

L Cabral, V Afreixo, R Meireles, M Vaz, M Marques… - BMC …, 2018 - Springer
Background Early sepsis diagnosis is crucial for the correct management of burn patients,
and it clearly influences outcomes. The systemic inflammatory response triggered by burns …