Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development

G Shen, F Zheng, D Ren, F Du, Q Dong, Z Wang… - Journal of hematology & …, 2018 - Springer
Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular
endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet …

Anlotinib: first global approval

YY Syed - Drugs, 2018 - Springer
Abstract Jiangsu Chia-Tai Tianqing Pharmaceutical and Advenchen Laboratories are co-
developing anlotinib (Focus V®) for the treatment of advanced cancer. Anlotinib is an oral …

Effect of anlotinib as a third-line or further treatment on overall survival of patients with advanced non–small cell lung cancer: the ALTER 0303 phase 3 randomized …

B Han, K Li, Q Wang, L Zhang, J Shi, Z Wang… - JAMA …, 2018 - jamanetwork.com
Importance Anlotinib is a novel multitarget tyrosine kinase inhibitor for tumor angiogenesis
and proliferative signaling. A phase 2 trial showed anlotinib to improve progression-free …

[HTML][HTML] Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p

F Kong, J Ma, H Yang, D Yang, C Wang… - Biochimica et Biophysica …, 2018 - Elsevier
The plasmacytoma variant translocation 1 (PVT1) 1 gene is a long non-coding RNA
(lncRNA) 2 that has been shown to be an oncogene in many cancers. Herein, the function …

Long pentraxin 3-mediated fibroblast growth factor trapping impairs fibrosarcoma growth

PF Rodrigues, S Matarazzo, F Maccarinelli… - Frontiers in …, 2018 - frontiersin.org
Fibrosarcomas are soft tissue mesenchymal tumors originating from transformed fibroblasts.
Fibroblast growth factor-2 (FGF2) and its tyrosine-kinase receptors (FGFRs) play pivotal …

FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models

SJ Stehbens, RJ Ju, MN Adams… - Journal of Cell …, 2018 - journals.biologists.com
Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases that
control a diverse range of biological processes during development and in adult tissues. We …

Use of anlotinib in intra-abdominal desmoplastic small round cell tumors: a case report and literature review

HM Chen, G Feng - OncoTargets and therapy, 2018 - Taylor & Francis
Background Intra-abdominal desmoplastic small round cell tumor (IADSRCT) is a highly
invasive malignant tumor that is rare in clinical practice. Anlotinib is a multitarget receptor …