Molecular mechanisms of viral oncogenesis in humans
NA Krump, J You - Nature Reviews Microbiology, 2018 - nature.com
Viral infection is a major contributor to the global cancer burden. Recent advances have
revealed that seven known oncogenic viruses promote tumorigenesis through shared host …
revealed that seven known oncogenic viruses promote tumorigenesis through shared host …
Detection of microbial infections through innate immune sensing of nucleic acids
Microbial infections are recognized by the innate immune system through germline-encoded
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …
Species-specific deamidation of cGAS by herpes simplex virus UL37 protein facilitates viral replication
Summary Herpes simplex virus 1 (HSV-1) establishes infections in humans and mice, but
some non-human primates exhibit resistance via unknown mechanisms. Innate immune …
some non-human primates exhibit resistance via unknown mechanisms. Innate immune …
cGAS and STING: At the intersection of DNA and RNA virus-sensing networks
As the first line of host defense, the innate immune system utilizes germline-encoded
receptors named pattern-recognition receptors (PRRs) to detect invading pathogens. PRRs …
receptors named pattern-recognition receptors (PRRs) to detect invading pathogens. PRRs …
Innate sensing of DNA virus genomes
DNA viruses are linked to many infectious diseases and contribute significantly to human
morbidity and mortality worldwide. Moreover, DNA viral infections are usually lifelong and …
morbidity and mortality worldwide. Moreover, DNA viral infections are usually lifelong and …
Human cytomegalovirus protein UL31 inhibits DNA sensing of cGAS to mediate immune evasion
ZF Huang, HM Zou, BW Liao, HY Zhang, Y Yang… - Cell host & …, 2018 - cell.com
The cytosolic DNA sensor cGAS recognizes viral DNA and synthesizes the second
messenger cGAMP upon viral infection. cGAMP binds to the adaptor protein MITA/STING to …
messenger cGAMP upon viral infection. cGAMP binds to the adaptor protein MITA/STING to …
Virulent poxviruses inhibit DNA sensing by preventing STING activation
Cytosolic recognition of DNA has emerged as a critical cellular mechanism of host immune
activation upon pathogen invasion. The central cytosolic DNA sensor cGAS activates STING …
activation upon pathogen invasion. The central cytosolic DNA sensor cGAS activates STING …
Interactome and proteome dynamics uncover immune modulatory associations of the pathogen sensing factor cGAS
Viral DNA sensing is an essential component of the mammalian innate immune response.
Upon binding viral DNA, the cyclic-GMP-AMP synthase (cGAS) catalyzes the production of …
Upon binding viral DNA, the cyclic-GMP-AMP synthase (cGAS) catalyzes the production of …
Caspase-dependent suppression of type I interferon signaling promotes Kaposi's sarcoma-associated herpesvirus lytic replication
T Tabtieng, A Degterev, MM Gaglia - Journal of virology, 2018 - Am Soc Microbiol
An important component of lytic infection by Kaposi's sarcoma-associated herpesvirus
(KSHV) is the ability of the virus to evade the innate immune response, specifically type I …
(KSHV) is the ability of the virus to evade the innate immune response, specifically type I …
The regulation of cGAS
M Xiong, S Wang, YY Wang, Y Ran - Virologica Sinica, 2018 - Springer
The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune
response against pathogens that contain DNA or with DNA production in their life cycles …
response against pathogens that contain DNA or with DNA production in their life cycles …